E-Cigarette Use Causes a Unique Innate Immune Response

[Bobsbeer]

A new study challenges the concept that e cigs are a safer alternative to smoking.  The authors do say it is a small study and the e cig users were also ex smokers, so clearly further research is needed before a true conclusion can be drawn.  No doubt this will be in the red tops in the next few days. 

"...our results challenge the concept
 that e-cigarettes are a healthier alternative to cigarettes and reverse smoking-induced adverse
 health effects..." 

www.thoracic.org/about/newsroom/press-releases/resources/ecigarette-health-harms.pdf

[MrDJ]

whatever crap they come up with it gets posted in all the papers and on the news and on social media.
when it is debunked do we see these reports removed, of course not.

so even if vaping was only 50% safer, or even 40/30% its still safer than smoking full stop.
so i will continue vaping and maybe in 10 or 20 years time they will finally give up with all this bloody scaremongering.
sadly in that time how many more people will die from smoking as they were scared to start vaping.

[domejunky]

Looks quite scholarly to me. Suggests that aldehydes from flavourings or overheating PG/VG are to blame.

Interestingly they tested actual capers, rather than extrapolating from a badly wicked atomiser...

[izan]

Oct 23, 2017 22:58:53 GMT domejunky said:

Looks quite scholarly to me. Suggests that aldehydes from flavourings or overheating PG/VG are to blame.

Interestingly they tested actual capers, rather than extrapolating from a badly wicked atomiser...

I'd not go that far. Junk science IS junk science.
Perhaps they need to consider that NICOTINE may be a bigger player than simply "Vaping".
Supposition and inference as well as the vague characterization of "Unique" demand that the study, with such a limited sample size, contain a statement of being inconclusive.
Being funded by the ANTZ, they found what they had been paid to find. And reported in kind.

Cheers
I

[jtc]

Me thinks it's still better than smoking whatever they come up with so I'll carry on regardless 😂😊👍

[DaveJ]

Oct 24, 2017 4:32:05 GMT jtc said:

Me thinks it's still better than smoking whatever they come up with so I'll carry on regardless 😂😊👍

Me too.

I'd believe Dr F (linky) before I took much notice of these fellows.

[Bobsbeer]

Oct 24, 2017 5:56:40 GMT DaveJ said:

Oct 24, 2017 4:32:05 GMT jtc said:

Me thinks it's still better than smoking whatever they come up with so I'll carry on regardless 😂😊👍

Me too.

I'd believe Dr F (linky) before I took much notice of these fellows.

While I too will carry on vaping, as no research would suggest that smoking is safer than e cigs, the study Dr F is quoting is a different study and looking at different things.  Reading this article they are in my view over hyping the results.  While they do show increased secretions compared to Non Smokers, the difference between Smokers and E Cig users was quite marked, and clearly showed that vaping was better than smoking.  To me that should be the headline.

Total mucin and individual MUC5AC and MUC5B concentrations in tobacco product users’
 sputum:

An increased total mucin concentration and a shift in the ratio between the major gelforming
 airway mucins MUC5B and MUC5AC have been shown to be correlated with cigarette smoking and COPD progression (31).

We observed that the total mucin concentrations in sputum
 samples were significantly increased (p=0.04) in cigarette smokers (1986 µg/ml +/- 810 SD)
 compared with non-smokers (1251 µg/ml +/- 964 SD) and that the total mucin concentrations in
 the sputum samples of the e-cigarette users, although slightly increased (1322 µg/ml +/- 663
 SD), were not significantly different from those in non-smokers’ samples (Fig. 6A). Analysis of
 the individual concentrations of MUC5B and MUC5AC (Fig. 6B, C) showed that MUC5B levels
 were not altered in the sputum of cigarette smokers or e-cigarette users and thus did not
 contribute to the observed increases in total mucin. MUC5AC concentrations, however, were
 significantly increased in cigarette smokers (132 pmol/ml +/- 58 SD, p=0.02) and in e-cigarette
 users (58 pmol/ml +/- 21 SD, p=0.05) compared with the non-smokers (15 pmol/ml +/- 6 SD).
 As a result, the MUC5AC/MUC5B ratio was significantly increased in cigarette smokers (0.32,
 p=0.02) and e-cigarette users (0.34, p=0.05) compared with non-smokers (0.11) (Fig. 6D).

[djs]

Perhaps if I fully understood " (an) Innate Immune Response" maybe I could make some sense of it all.

[Richard46]

Oct 24, 2017 13:45:21 GMT djs said:

Perhaps if I fully understood " (an) Innate Immune Response" maybe I could make some sense of it all.

Indeed something else to worry about that we (well me and you anyway) had never heard of until today.
Do many people die from it? Or is it a lack of it?
Will I actually start worrying about it. No.

[djs]

Oct 24, 2017 16:05:32 GMT Richard46 said:

Do many people die from it? Or is it a lack of it?
Will I actually start worrying about it. No.

Agreed. If the numbers are anything to go by.

Non-smokers 1251
E-cig users 1322
Smokers 1986

I make the increase 5% above not-smoking. Almost 60% for smokers. The fact anything is measurable in a non-smoker means it exists, it's there already.

Sleep losing... No.

[Bobsbeer]

I'm not losing sleep either djs, I'm celebrating. The results may not show that vaping is harmless, but it does show that it is a hell of a lot better than smoking, and that's enough for me.